Closing the gap between adverse health effects of aluminum and its mechanisms of action
still represents a huge challenge. Cholinergic dysfunction has been implicated in neuronal
injury induced by aluminum. Previously reported data also indicate that in vivo and in vitro
exposure to aluminum inhibits the mammalian (Na+/K+) ATPase, an ubiquitous plasma
membrane pump. This study was undertaken with the specific aim of determining whether in
vitro exposure to AlCl3 and ouabain, the foremost utilized selective inhibitor of (Na+/K+) …